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KMID : 1190620140100020067
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Journal of the Korean Wound Care Society
2014 Volume.10 No. 2 p.67 ~ p.74
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Effect of Hyaluronic Acid Dressing on Diabetic Ulcer Healing - A Pilot Study -
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Lee Ye-Na
Yun Tae-Kyoung
Han Seung-Kyu
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Abstract
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To compare the clinical efficacy and safety of hyaluronic acid (HA) dressing with that of conventional dressing material in the management of diabetic foot ulcers. From May 2013 to February 2014, 19 patients with diabetic foot ulcers were randomized to either the control group with conventional dressing (n=9) or the experimental group with HA dressing(HealodermTM) (n=10). Weekly assessments containing wound size and depth, wound characteristics, adverse events,
and gross photographs were performed by single investigator. Percentages of reduction in terms of wound area and percentage of increment of healthy granulation tissue were measured for each patient in both groups. By week 3, the mean percentage of wound area reduction was 51.6% in the experimental group and 29.7% in the control group (P=0.184). The mean percentage of wound depth reduction was 59.3% in the experimental group and 50.7% in the experimental group (P=0.712). In addition, the mean percentage of increment of healthy granulation tissue area was 51.7% in the experimental group and 14.6% in the control group (P=0.60). No adverse events related to the study treatment occurred. HA dressing may have a potential to accelerate the diabetic wound healing. (J Korean Wound Management Soc 2014;10:67-74)
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KEYWORD
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Diabetic foot, Hyaluronic acid dressing
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